Autophagy regulation by p53.

  title={Autophagy regulation by p53.},
  author={Maria Chiara Maiuri and Lorenzo Galluzzi and Eugenia Morselli and Oliver Kepp and Shoaib A. Malik and Guido Kroemer},
  journal={Current opinion in cell biology},
  volume={22 2},
Autophagy is an evolutionarily conserved catabolic pathway that is involved in numerous physiological processes and in multiple pathological conditions including cancer. Autophagy is regulated by an intricate network of signaling cascades that have not yet been entirely disentangled. Accumulating evidence indicates that p53, the best-characterized human tumor suppressor protein, can modulate autophagy in a dual fashion, depending on its subcellular localization. On the one hand, p53 functions… CONTINUE READING
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