Autophagy-regulating small molecules and their therapeutic applications.

  title={Autophagy-regulating small molecules and their therapeutic applications.},
  author={Kyung-Hwa Baek and Jihye Park and Injae Shin},
  journal={Chemical Society reviews},
  volume={41 8},
Autophagy or self-eating is a complicated cellular process that is involved in protein and organelle digestion occurring via a lysosome-dependent pathway. This process is of great importance in maintaining normal cellular homeostasis. However, disruption of autophagy is closely associated with various human diseases such as cancer, neurodegenerative disorders, heart disease and pathogen infection. Therefore, small molecules that modulate autophagy can be employed to dissect this complex process… CONTINUE READING


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