Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.

@article{Ouimet2011AutophagyRC,
  title={Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.},
  author={Mireille Ouimet and Vivian Franklin and Esther W. M. Mak and Xianghai Liao and I ra Tabas and Yves L. Marcel},
  journal={Cell metabolism},
  year={2011},
  volume={13 6},
  pages={655-67}
}
The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as cholesteryl esters (CEs), is liberated from this organelle and delivered to cholesterol acceptors. The current paradigm attributes all cytoplasmic CE hydrolysis to the… CONTINUE READING