Autophagy regulates adipose mass and differentiation in mice.

@article{Singh2009AutophagyRA,
  title={Autophagy regulates adipose mass and differentiation in mice.},
  author={R K Dhanjit Singh and Youqing Xiang and Yongjun Wang and Kiran K. Baikati and Ana Mar{\'i}a Cuervo and Yen K. Luu and Yan Tang and Jeffrey Eugene Pessin and Gary J Schwartz and Mark J Czaja},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 11},
  pages={
          3329-39
        }
}
The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage and whole-body energy homeostasis. However, the mechanisms regulating the formation, expansion, and interconversion of these 2 distinct types of fat remain unknown. Recently, the lysosomal degradative pathway of macroautophagy has been identified as a regulator of cellular differentiation, suggesting that autophagy may modulate this process in adipocytes. The function of autophagy in… CONTINUE READING

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