Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

@inproceedings{Romao2013AutophagyPS,
  title={Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing},
  author={Susana Romao and Nathalie Gasser and Andrea C. Becker and Bruno Guhl and Milica Bajagic and Danusia Vanoaica and Urs Ziegler and Joachim Roesler and Joern Dengjel and Janine Reichenbach and Christian M{\"u}nz},
  booktitle={The Journal of cell biology},
  year={2013}
}
Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility… CONTINUE READING