Autophagy proteins regulate the secretory component of osteoclastic bone resorption.

Abstract

Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the plasmalemma results in acidification of the resorptive microenvironment and release of CatK to digest the organic matrix of bone. The means by which secretory lysosomes are directed to… (More)
DOI: 10.1016/j.devcel.2011.08.016

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Cite this paper

@article{Deselm2011AutophagyPR, title={Autophagy proteins regulate the secretory component of osteoclastic bone resorption.}, author={Carl J Deselm and Brian C Miller and Wei Zou and Wandy L. Beatty and Eline van Meel and Yoshifumi Takahata and Judith Klumperman and Sharon A Tooze and Steven L Teitelbaum and Herbert W Virgin}, journal={Developmental cell}, year={2011}, volume={21 5}, pages={966-74} }