Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling.

@article{Shen2015AutophagyPC,
  title={Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling.},
  author={Chenxi Shen and Guo Cai and Jiangyun Peng and Xianjin Chen},
  journal={Osteoarthritis and cartilage},
  year={2015},
  volume={23 12},
  pages={
          2279-2287
        }
}
OBJECTIVE Glucocorticoids (GCs) have been widely used in the management of osteoarthritis (OA) and rheumatoid arthritis (RA). Nevertheless, there has been some concern about their ability of increasing reactive oxygen species (ROS) in the cartilage. Forkhead-box class O (FOXO) transcription factors have been proved to have a protective role in chondrocytes through regulation of autophagy and defending oxidative stress. The objective of this study was to investigate the role of FOXO3 in Dex… CONTINUE READING
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Defective autophagy in chondrocytes with Kashin-Beck disease but drocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 joca.2015.06.020

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