Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.

@article{Paris2011AutophagyPA,
  title={Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.},
  author={Irmgard B. Paris and Patricia Mu{\~n}oz and Sandro Huenchuguala and Eduardo Couve and Laurie H Sanders and J Timothy Greenamyre and Pablo Caviedes and Juan Segura-Aguilar},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={121 2},
  pages={
          376-88
        }
}
Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanin-containing dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent cell death in a cell line derived from rat substantia nigra. We found that aminochrome (50μM), in the presence of NAD(P)H-quinone oxidoreductase, EC 1.6.99.2 (DT)-diaphorase inhibitor dicoumarol (DIC) (100μM), induces significant cell death (62 ± 3%; p < 0.01), increase… CONTINUE READING

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