Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells.

@article{Huang2014AutophagyPR,
  title={Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells.},
  author={Yao-Huei Huang and P M Yang and Qiu-Yu Chuah and Y Lee and Yi-Fen Hsieh and Chih-Wen Peng and Shu-Jun Chiu},
  journal={Autophagy},
  year={2014},
  volume={10 7},
  pages={1212-28}
}
Ionizing radiation induces cellular senescence to suppress cancer cell proliferation. However, it also induces deleterious bystander effects in the unirradiated neighboring cells through the release of senescence-associated secretory phenotypes (SASPs) that promote tumor progression. Although autophagy has been reported to promote senescence, its role is still unclear. We previously showed that radiation induces senescence in PTTG1-depleted cancer cells. In this study, we found that autophagy… CONTINUE READING

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