Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells.

@article{Karlsson2013AutophagyOI,
  title={Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells.},
  author={Markus Karlsson and Christina I. Frennesson and Therese Gustafsson and Ulf T. Brunk and Sven Erik G. Nilsson and Tino Kurz},
  journal={Experimental eye research},
  year={2013},
  volume={116},
  pages={359-65}
}
The objective of this study was to elucidate possible reasons for the remarkable resistance of human retinal pigment epithelial (RPE) cells to oxidative stress. Much oxidative damage is due to hydrogen peroxide meeting redox-active iron in the acidic and reducing lysosomal environment, resulting in the production of toxic hydroxyl radicals that may oxidize intralysosomal content, leading to lipofuscin (LF) formation or, if more extensive, to permeabilization of lysosomal membranes. Formation of… CONTINUE READING

Similar Papers

Loading similar papers…