Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication.

@article{Checroun2006AutophagymediatedRO,
  title={Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication.},
  author={Claire Checroun and Tara D. Wehrly and Elizabeth R. Fischer and Stanley F. Hayes and Jean Celli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 39},
  pages={14578-83}
}
Intracellular bacterial pathogens evade the bactericidal functions of mammalian cells by physical escape from their phagosome and replication into the cytoplasm or through the modulation of phagosome maturation and biogenesis of a membrane-bound replicative organelle. Here, we detail in murine primary macrophages the intracellular life cycle of Francisella tularensis, a highly infectious bacterium that survives and replicates within mammalian cells. After transient interactions with the… CONTINUE READING
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