Autophagy-lysosomal pathway is involved in lipid degradation in rat liver.

  title={Autophagy-lysosomal pathway is involved in lipid degradation in rat liver.},
  author={Vojtěch {\vS}kop and M Cahova and Zuzana Papackova and Eliska Palenickova and Helena Dankova and Michael Baranowski and Piotr Zabielski and Jana Zdychov{\'a} and Jarmila Z{\'i}dkov{\'a} and Ludmila Kazdov{\'a}},
  journal={Physiological research},
  volume={61 3},
We present data supporting the hypothesis that the lysosomal-autophagy pathway is involved in the degradation of intracellular triacylglycerols in the liver. In primary hepatocytes cultivated in the absence of exogenous fatty acids (FFA), both inhibition of autophagy flux (asparagine) or lysosomal activity (chloroquine) decreased secretion of VLDL (very low density lipoproteins) and formation of FFA oxidative products while the stimulation of autophagy by rapamycine increased some of these… CONTINUE READING