Autophagy is required for necrotic cell death in Caenorhabditis elegans

  title={Autophagy is required for necrotic cell death in Caenorhabditis elegans},
  author={Chrysanthi Samara and Popi Syntichaki and Nektarios Tavernarakis},
  journal={Cell Death and Differentiation},
Autophagy is the main process for bulk protein and organelle recycling in cells under extracellular or intracellular stress. Deregulation of autophagy has been associated with pathological conditions such as cancer, muscular disorders and neurodegeneration. Necrotic cell death underlies extensive neuronal loss in acute neurodegenerative episodes such as ischemic stroke. We find that excessive autophagosome formation is induced early during necrotic cell death in C. elegans. In addition… CONTINUE READING
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