Autophagy is required for glucose homeostasis and lung tumor maintenance.

  title={Autophagy is required for glucose homeostasis and lung tumor maintenance.},
  author={Gizem Karsli-Uzunbas and Jessie Guo and Sandy Price and Xin Teng and Saurabh V. Laddha and Sinan Khor and Nada Y Kalaany and Tyler E. Jacks and Chang S. Chan and Joshua D. Rabinowitz and E. P. White},
  journal={Cancer discovery},
  volume={4 8},
UNLABELLED Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity. To assess the functional significance of autophagy in both normal and tumor tissue, we conditionally deleted the essential autophagy gene, autophagy related 7 (Atg7), throughout adult mice. Here, we report that systemic ATG7 ablation… CONTINUE READING
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