Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance.

@article{Lira2013AutophagyIR,
  title={Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance.},
  author={Vitor A Lira and Mitsuharu Okutsu and Mei Zhang and Nicholas P. Greene and Rhianna C. Laker and David S. Breen and Kyle L Hoehn and Zhen Yan},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 10},
  pages={4184-93}
}
Pathological and physiological stimuli, including acute exercise, activate autophagy; however, it is unknown whether exercise training alters basal levels of autophagy and whether autophagy is required for skeletal muscle adaptation to training. We observed greater autophagy flux (i.e., a combination of increased LC3-II/LC3-I ratio and LC3-II levels and reduced p62 protein content indicating a higher rate of initiation and resolution of autophagic events), autophagy protein expression (i.e… CONTINUE READING
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