Autophagy is required for dietary restriction-mediated life span extension in C. elegans.

@article{Jia2007AutophagyIR,
  title={Autophagy is required for dietary restriction-mediated life span extension in C. elegans.},
  author={Kailiang Jia and Beth Levine},
  journal={Autophagy},
  year={2007},
  volume={3 6},
  pages={597-9}
}
Dietary restriction extends life span in diverse species including Caenorhabditis elegans. However, the downstream cellular targets regulated by dietary restriction are largely unknown. Autophagy, an evolutionary conserved lysosomal degradation pathway, is induced under starvation conditions and regulates life span in insulin signaling C. elegans mutants. We now report that two essential autophagy genes (bec-1 and Ce-atg7) are required for the longevity phenotype of the C. elegans dietary… CONTINUE READING

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