Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

  title={Autophagy is activated in systemic lupus erythematosus and required for plasmablast development},
  author={Alexander J Clarke and Ursula Ellinghaus and Andrea Cortini and Amanda J. Stranks and Anna Katharina Simon and Marina Botto and Timothy J Vyse},
  booktitle={Annals of the rheumatic diseases},
BACKGROUND Autophagy has emerged as a critical homeostatic mechanism in T lymphocytes, influencing proliferation and differentiation. Autophagy in B cells has been less studied, but genetic deficiency causes impairment of early and late developmental stages OBJECTIVES To explore the role of autophagy in the pathogenesis of human and murine lupus, a disease in which B cells are critical effectors of pathology. METHODS Autophagy was assessed using multiple techniques in NZB/W and control mice… CONTINUE READING
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T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2012

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