Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation.

@article{Deretic2012AutophagyIW,
  title={Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation.},
  author={Vojo Deretic and Shanya Jiang and Nicolas Dupont},
  journal={Trends in cell biology},
  year={2012},
  volume={22 8},
  pages={397-406}
}
Autophagy is a cell biological process ubiquitous to all eukaryotic cells, often referred to as a catabolic, lysosomal degradative pathway. However, current studies in mammalian systems suggest that autophagy plays an unexpectedly broad biogenesis role in protein trafficking and secretion. Autophagy supports alternative trafficking pathways for delivery of integral membrane proteins to the plasma membrane and affects secretion, including the constitutive, regulated and unconventional secretion… CONTINUE READING

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