Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells.

  title={Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells.},
  author={Seoung Woo Shin and Sung Youl Kim and Jeen-Woo Park},
  journal={Biochimica et biophysica acta},
  volume={1823 2},
The phosphoinositol 3-kinase/Akt pathway plays a critical role in oncogenesis and the dysregulation of this pathway through loss of PTEN is a particularly common phenomenon in aggressive prostate cancers. Several recent studies have indicated that ursolic acid (UA), a pentacyclic triterpenoid, and its derivatives inhibit the growth of cancer cells by cell cycle arrest and the stimulation of apoptosis. In the present study, we report a novel autophagic response of UA in PTEN-deficient PC3… CONTINUE READING


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