Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death.

  title={Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death.},
  author={Sandrine Eimer and Marc-Antoine Belaud-Rotureau and Kelly Airiau and Marie Jeanneteau and Elodie Laharanne and Nad{\`e}ge V{\'e}ron and Anne Vital and Hugues Loiseau and Jean-Philippe Merlio and Françis Belloc},
  journal={Cancer biology & therapy},
  volume={11 12},
Gliomas are the most common malignant primary brain tumors in adults. The median survival never exceeds 12 months, owing to inherent resistance to both radio and chemotherapies. Epidermal Growth Factor Receptor (EGFR) is amplified, overexpressed, and/or mutated in glioblastomas (GBM), making it a rational for therapy. Erlotinib, an EGFR kinase inhibitor is strongly associated with clinical response in several cancers. Inhibition of cell proliferation and induction of apoptosis by erlotinib were… CONTINUE READING


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