Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability.

@article{Wang2020AutophagyinhibitingPA,
  title={Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability.},
  author={J. Wang and Xuefei Zhou and H. Wang and Qian Xiao and K. Ding and X. Dong and Shufeng Xu and B. Shen and Jihong Sun and Zhuxian Zhou and Jianbin Tang and Xiangrui Liu and Youqing Shen},
  journal={Biomaterials},
  year={2020},
  volume={255},
  pages={
          120156
        }
}
  • J. Wang, Xuefei Zhou, +10 authors Youqing Shen
  • Published 2020
  • Medicine, Materials Science
  • Biomaterials
  • Conventionally, polycations are pharmacological inert used as nonviral gene delivery vectors with the sole function of compacting and protecting nucleic acids. Here, the first autophagy-inhibiting cationic polymer delivering plasmid DNA (pDNA) encoding TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is prepared for cancer gene therapy. The copolymerization of methacryloyl chloroquine (MACQ) with 2-(dimethylamino)ethyl methacrylate (DMAEMA) not only improves transfection efficacy… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 55 REFERENCES
    Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
    • 648
    • Open Access
    Recent insights into the function of autophagy in cancer.
    • 252
    • Open Access