Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.

@article{Lin2010AutophagyIW,
  title={Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.},
  author={Chi-Iou Lin and Edward E. Whang and David B. Donner and Jinyan Du and Jochen H. Lorch and Frank He and Xiaofeng Jiang and Brendan D. Price and Francis D. Moore and Daniel T. Ruan},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 9},
  pages={1217-26}
}
Although autophagy is generally considered a prosurvival mechanism that preserves viability, there is evidence that it could drive an alternative programmed cell death pathway in cells with defects in apoptosis. Because the inhibition of autophagic activity promotes resistance to both chemotherapy and external beam radiation in papillary thyroid cancer (PTC), we determined if RAD001, a potent activator of autophagy, improves the efficacy of either therapy. We found that RAD001 increased the… CONTINUE READING

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