Autophagy induction as a therapeutic strategy for neurodegenerative diseases.
@article{Djajadikerta2019AutophagyIA, title={Autophagy induction as a therapeutic strategy for neurodegenerative diseases.}, author={Alvin Djajadikerta and Swati Keshri and Mariana Pavel and Ryan Prestil and Laura Ryan and David C. Rubinsztein}, journal={Journal of molecular biology}, year={2019} }
77 Citations
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment.
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This review summarizes the current knowledge about autophagy in MS, in particular how it contributes to the understanding of MS pathology and its potential as a novel therapeutic target.
The contribution of altered neuronal autophagy to neurodegeneration.
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Natural Compounds and Autophagy: Allies Against Neurodegeneration
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This review focuses on the role of dietary phytochemicals as modulators of autophagy to fight Alzheimer's and Parkinson’s diseases, fronto-temporal dementia, amyotrophic lateral sclerosis, and psychiatric disorders.
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The discovery of small molecules or natural products capable of enhancing autophagy mechanism could be a promising strategy for PD treatment as it provides symptomatic relieve for motor symptoms without significant improvement in non-motor complications.
Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases
- Biology, ChemistryFrontiers in Cell and Developmental Biology
- 2020
Target therapies aimed at protecting the Golgi or regulating Golgi proteins might prevent or ameliorate autophagy-related neurological diseases, as well as investigate the potential application of Golgi therapy in autophagic-based neurological diseases.
Bi-Directional Relationship Between Autophagy and Inflammasomes in Neurodegenerative Disorders.
- BiologyCellular and molecular neurobiology
- 2022
The structural basis of inflammasome activation and the mechanistic ideas of the autophagy process in NDs are discussed and a perspective on pharmacological opportunities in this molecular interplay pertaining to NDs is presented.
The Emerging Roles of Autophagy in Human Diseases
- Biology, MedicineBiomedicines
- 2021
Advances in understanding the roles of autophagy in human diseases and the therapeutic methods targeting autophapy are summarized and some of the remaining questions in this field are discussed, focusing on cancer, neurodegenerative diseases, infectious diseases and metabolic disorders.
Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration
- BiologyNeural regeneration research
- 2022
Together, these studies illustrate an important role for microglial LANDO in regulating CNS immune activation and protection against neurodegeneration and could have significant impact in furthering the authors' understanding of not only CNS diseases like AD, but likely beyond.
KDM1A/LSD1 as a promising target in various diseases treatment by regulating autophagy network.
- Biology, ChemistryBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2022
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