Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.

@article{Reed2013AutophagyinducingPB,
  title={Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.},
  author={Michelle Reed and Susan H. Morris and Sihyug Jang and Sumanta Mukherjee and Zhenyu Yue and Nicholas W Lukacs},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={2526-37}
}
Recent work demonstrated the importance of macroautophagy in dendritic cell (DC) maturation and innate cytokine production upon viral infection through delivery of cytoplasmic viral components to intracellular TLRs. To study the functional consequences of impaired autophagosome formation during a respiratory syncytial virus (RSV) infection, mice harboring significant autophagy defects due to Beclin-1 haploinsufficiency (Beclin-1(+/-)) were used. Upon RSV infection in vivo, lungs of Beclin-1… CONTINUE READING
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