Autophagy-induced tumor dormancy in ovarian cancer.

  title={Autophagy-induced tumor dormancy in ovarian cancer.},
  author={Ravi K Amaravadi},
  journal={The Journal of clinical investigation},
  volume={118 12},
Autophagy--a process of "self-eating" that involves enzymatic digestion and recycling of cellular constituents in response to stress--contributes to both cancer cell death and survival. In this issue of the JCI, Lu et al. report that controlled induction of tumor suppressor gene aplasia Ras homolog member I (ARHI) results in autophagic cell death of human ovarian cancer cells in vitro (see the related article beginning on page 3917). However, within xenograft tumors in mice, multiple factors… CONTINUE READING


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