Autophagy induced by FTY720 promotes apoptosis in U266 cells.

  title={Autophagy induced by FTY720 promotes apoptosis in U266 cells.},
  author={Aijun Liao and Rong Hu and Qihui Zhao and Jie Li and Yingchun Li and Kun Yao and Rong Zhang and Huihan Wang and Wei Yang and Zhuo-gang Liu},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={45 5},
Despite recent treatment advances, multiple myeloma (MM) remains incurable and patients develop a progressively relapsing disease with subsequent poor prognosis. Studies have shown FTY720 has activities against a number of hematological malignancies including MM, no reports about autophagy induced by FTY720 in MM. Therefore, we investigated the potential application of FTY720 on MM using U266 cell line. We observed that FTY720 could induce caspase-3 dependent apoptosis in a dose- and time… CONTINUE READING
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