Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination

@inproceedings{Liu2017AutophagyIB,
  title={Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination},
  author={Xingguang Liu and Hao Cao and Jian Li and Bo Wang and Ping Zhang and Xu Dong Zhang and Zhongmin Liu and Hongbin -B Yuan and Zhenzhen Zhan},
  booktitle={Cell Death and Differentiation},
  year={2017}
}
Lung ischemia-reperfusion (I/R) injury remains one of the most common complications after various cardiopulmonary surgeries. The inflammation response triggered by the released damage-associated molecular patterns (DAMPs) aggravates lung tissue damage. However, little is known about the role of autophagy in the pathogenesis of lung I/R injury. Here, we report that a variety of inflammation-related and autophagy-associated genes are rapidly upregulated, which facilitate the inflammation response… CONTINUE READING
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