Autophagy in tuberculosis.

  title={Autophagy in tuberculosis.},
  author={Vojo Deretic},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={4 11},
Autophagy as an immune mechanism controls inflammation and acts as a cell-autonomous defense against intracellular microbes including Mycobacterium tuberculosis. An equally significant role of autophagy is its anti-inflammatory and tissue-sparing function. This combination of antimicrobial and anti-inflammatory actions prevents active disease in animal models. In human populations, genetic links between autophagy, inflammatory bowel disease, and susceptibility to tuberculosis provide further… CONTINUE READING
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