Autophagy in the heart: too much of a good thing?

  title={Autophagy in the heart: too much of a good thing?},
  author={Erika Yan Wang and Agnieszka K Biala and Joseph W Gordon and Lorrie A. Kirshenbaum},
  journal={Journal of cardiovascular pharmacology},
  volume={60 2},
Autophagy constitutes a catabolic process involving lysosomal degradation of damaged and redundant cytosolic components into biomolecules, via an elaborate lysosomal pathway. Autophagy is a highly regulated and evolutionary conserved process crucial for normal tissue homeostasis and cell life. Certain members of the Bcl-2 gene family, including the BH3 only protein Bnip3 regulate autophagy during cardiac stress during ischemic or hypoxic injury as means of discarding damaged mitochondria and… CONTINUE READING

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