Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.

@article{MartinezLopez2016AutophagyIT,
  title={Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.},
  author={Nuria Martinez-Lopez and Marina Garc{\'i}a-Macia and Srabani Sahu and Diana Athonvarangkul and Emily J Liebling and Paola Merlo and Francesco Cecconi and Gary J Schwartz and Rajat Singh},
  journal={Cell metabolism},
  year={2016},
  volume={23 1},
  pages={113-27}
}
The integrative physiology of inter-organ communication in lipophagy regulation is not well understood. Lipophagy and the cytosolic lipases ATGL and HSL contribute to lipid droplet (LD) mobilization; however, whether autophagy proteins engage with lipases to promote lipid utilization remains unknown. Here, we show that cold induces autophagy in… CONTINUE READING