Autophagy in stem cell maintenance and differentiation.

  title={Autophagy in stem cell maintenance and differentiation.},
  author={Alexandre Teixeira Vessoni and Alysson Renato Muotri and Oswaldo Keith Okamoto},
  journal={Stem cells and development},
  volume={21 4},
Autophagy is a lysosome-dependent degradation pathway that allows cells to recycle damaged or superfluous cytoplasmic content, such as proteins, organelles, and lipids. As a consequence of autophagy, the cells generate metabolic precursors for macromolecular biosynthesis or ATP generation. Deficiencies in this pathway were associated to several pathological conditions, such as neurodegenerative and cardiac diseases, cancer, and aging. The aim of this review is to summarize recent discoveries… CONTINUE READING


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