Autophagy in regulation of Toll-like receptor signaling.

  title={Autophagy in regulation of Toll-like receptor signaling.},
  author={Takeshi Into and Megumi Inomata and Eiji Takayama and Toshiya Takigawa},
  journal={Cellular signalling},
  volume={24 6},
Toll-like receptors (TLRs) serve as the major innate immune sensors for detection of specific molecular patterns on various pathogens. TLRs activate signaling events mainly by utilizing ubiquitin-dependent mechanisms. Recent research advances have provided evidence that TLR signaling is linked to induction of autophagy. Autophagy is currently known to affect both of the immune defense and suppression of inflammatory responses. In TLR-associated immune responses, autophagic lysis of… CONTINUE READING
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