Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis.

  title={Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis.},
  author={Ming Jiang and W. Gray Jerome and Simon W Hayward},
  volume={6 1},
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we characterized in vitro and in vivo models of PPARgamma- and PPARgamma2-deficiency in mouse prostate epithelia. Autophagy accompanied the altered cellular proliferation and de… CONTINUE READING


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