Autophagy in nonalcoholic steatohepatitis.

@article{Amir2011AutophagyIN,
  title={Autophagy in nonalcoholic steatohepatitis.},
  author={Muhammad Husain Amir and Mark J Czaja},
  journal={Expert review of gastroenterology & hepatology},
  year={2011},
  volume={5 2},
  pages={
          159-66
        }
}
Autophagy is a critical pathway for the degradation of intracellular components by lysosomes. Established functions for both macroautophagy and chaperone-mediated autophagy in hepatic lipid metabolism, insulin sensitivity and cellular injury suggest a number of potential mechanistic roles for autophagy in nonalcoholic steatohepatitis (NASH). Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury… CONTINUE READING
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