Autophagy in neuronal cell loss: a road to death.

  title={Autophagy in neuronal cell loss: a road to death.},
  author={Krisztina Tak{\'a}cs-Vellai and Andrew W L Bayci and Tibor Vellai},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={28 11},
The regulation of ageing has been extensively studied in divergent animal model systems including worms, flies and mice. However, little is known about the cellular pathways that mediate the death of these organisms. Analysing major cellular changes in the ageing nematode Caenorhabditis elegans has revealed a gradual, progressive deterioration of different tissues except for the nervous system, which remarkably preserves its integrity even in advanced old age. In addition, genetic data have… CONTINUE READING

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