Autophagy in ischemic heart disease.

  title={Autophagy in ischemic heart disease.},
  author={{\AA} B Gustafsson and Roberta A Gottlieb},
  journal={Circulation research},
  volume={104 2},
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules and organelles. It plays a critical role in removing protein aggregates, as well as damaged or excess organelles, to maintain intracellular homeostasis and to keep the cell healthy. In the heart, autophagy occurs at low levels under normal conditions, and defects in this process cause cardiac dysfunction and heart failure. However, this pathway is rapidly upregulated under environmental stress… CONTINUE READING


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