Autophagy in innate and adaptive immunity against intracellular pathogens

  title={Autophagy in innate and adaptive immunity against intracellular pathogens},
  author={Dorothee Schmid and J{\"o}rn Dengjel and Oliver Schoor and Stefan Stevanovi{\'c} and Christian M{\"u}nz},
  journal={Journal of Molecular Medicine},
Autophagy delivers cytoplasmic constituents for lysosomal degradation. Recent studies have demonstrated that this pathway mediates resistance to pathogens and is targeted for immune evasion by viruses and bacteria. Lysosomal degradation products, including pathogenic determinants, are then surveyed by the adaptive immune system to elicit antigen-specific T cell responses. CD4+ T helper cells have been shown to recognize nuclear and cytosolic antigens via presentation by major histocompatibility… CONTINUE READING


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