Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview.

@article{Mehrpour2010AutophagyIH,
  title={Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview.},
  author={Maryam Mehrpour and Audrey Esclatine and Isabelle Beau and Patrice Codogno},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 4},
  pages={
          C776-85
        }
}
Macroautophagy is a vacuolar degradation pathway that terminates in the lysosomal compartment after formation of a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The identification of ATG (autophagy-related) genes that are involved in the formation of autophagosomes has greatly increased our knowledge of the molecular basis of macroautophagy, and its roles in cell function, which extend far beyond degradation and quality control of the cytoplasm. Macroautophagy… 
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