Autophagy in Neurodegeneration: Can't Digest It, Spit It Out!


The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear… (More)
DOI: 10.1016/j.tcb.2018.01.001


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