Autophagy in Huntington disease and huntingtin in autophagy

  title={Autophagy in Huntington disease and huntingtin in autophagy},
  author={Dale David Orr Martin and Safia Ladha and Dagmar E Ehrnhoefer and Michael R. Hayden},
  journal={Trends in Neurosciences},
Autophagy is an important biological process that is essential for the removal of damaged organelles and toxic or aggregated proteins by delivering them to the lysosome for degradation. Consequently, autophagy has become a primary target for the treatment of neurodegenerative diseases that involve aggregating proteins. In Huntington disease (HD), an expansion of the polyglutamine (polyQ) tract in the N-terminus of the huntingtin (HTT) protein leads to protein aggregation. However, HD is unique… CONTINUE READING

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