Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells

@article{Li2009AutophagyFM,
  title={Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells},
  author={Bo Li and Zhang Lei and Brain D. Lichty and Dong Li and Gui-mei Zhang and Zuo-hua Feng and Yonghong Wan and Bo Huang},
  journal={Cancer Immunology, Immunotherapy},
  year={2009},
  volume={59},
  pages={313-321}
}
The reduction or loss of MHC-I antigen surface expression in human and murine tumor cells is partly attributable to the dysregulation of various components of the MHC-I antigen-processing machinery. Accumulating evidence suggests that autophagy, besides its vital role in maintaining the cellular homeostasis, plays an important role in MHC-II surface expression. Here, we report that autophagy is a negative regulator of MHC-I antigen expression in B16 melanoma cells; however, in the presence of… CONTINUE READING
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