Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.

@article{Zhan2014AutophagyFT,
  title={Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.},
  author={Zhenzhen Zhan and Xuefeng Xie and Hao Cao and Xiaohui Zhou and Huimin Fan and Zhongmin Liu},
  journal={Autophagy},
  year={2014},
  volume={10 2},
  pages={
          257-68
        }
}
Autophagy contributes to the pathogenesis of cancer, whereas toll-like receptors (TLRs) also play an important role in cancer development and immune escape. However, little is known about the potential interaction between TLR signaling and autophagy in cancer cells. Here we show that autophagy induced by TLR4 or TLR3 activation enhances various cytokine productions through promoting TRAF6 (TNF receptor-associated factor 6, E3 ubiquitin protein ligase) ubiquitination and thus facilitates… CONTINUE READING
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