Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.


Autophagy is regulated for IFN-gamma-mediated antimicrobial efficacy; however, its molecular effects for IFN-gamma signaling are largely unknown. Here, we show that autophagy facilitates IFN-gamma-activated Jak2-STAT1. IFN-gamma induces autophagy in wild-type but not in autophagy protein 5 (Atg5(-/-))-deficient mouse embryonic fibroblasts (MEFs), and… (More)
DOI: 10.1074/jbc.M110.133355


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