Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion.

@article{Lock2014AutophagydependentPO,
  title={Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion.},
  author={Rebecca C Lock and Candia M. Kenific and Andrew Michael Leidal and Eduardo Salas and Jayanta Debnath},
  journal={Cancer discovery},
  year={2014},
  volume={4 4},
  pages={
          466-79
        }
}
UNLABELLED The tumor-promoting functions of autophagy are primarily attributed to its ability to promote cancer cell survival. However, emerging evidence suggests that autophagy plays other roles during tumorigenesis. Here, we uncover that autophagy promotes oncogenic RAS-driven invasion. In epithelial cells transformed with oncogenic RAS, depletion of autophagy-related genes suppresses invasion in three-dimensional culture, decreases cell motility, and reduces pulmonary metastases in vivo… CONTINUE READING

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