Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein.

@article{Isakson2010AutophagyCT,
  title={Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein.},
  author={Pauline Isakson and Magnar Bj\or{\aa}s and Stig Ove B\oe and Anne Simonsen},
  journal={Blood},
  year={2010},
  volume={116 13},
  pages={2324-31}
}
Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid and/or arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARA). The authors of previous studies have implicated the ubiquitin-proteasome pathway as the main mechanism involved in therapy-induced PML/RARA degradation. Here we have investigated a role… CONTINUE READING
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