Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis

Abstract

Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP). While the large-scale mitochondrial release of pro-apoptotic proteins activates caspase-dependent cell death, a limited release results in sub… (More)
DOI: 10.1186/s12964-015-0115-9

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Cite this paper

@inproceedings{Choe2015AutophagyCA, title={Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis}, author={Sehyo Charley Choe and Anne Hamacher-Brady and Nathan R. Brady}, booktitle={Cell Communication and Signaling}, year={2015} }