Autophagy as an immune effector against tuberculosis.

  title={Autophagy as an immune effector against tuberculosis.},
  author={Steven B. Bradfute and Eliseo F Castillo and John Arko-Mensah and Santosh Chauhan and Shanya Jiang and Michael A Mandell and Vojo Deretic},
  journal={Current opinion in microbiology},
  volume={16 3},
The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue… CONTINUE READING
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