Autophagy and neurodegeneration.

  title={Autophagy and neurodegeneration.},
  author={Rebecca A Frake and Thomas Ricketts and Fiona Mhairi Menzies and David C Rubinsztein},
  journal={The Journal of clinical investigation},
  volume={125 1},
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also… CONTINUE READING