Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma.

  title={Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma.},
  author={Silvia Palumbo and Sergio Comincini},
  journal={Journal of cellular physiology},
  volume={228 1},
Autophagy is a so-called "self-eating" system responsible for degrading long-lived proteins and cytoplasmic organelles, whose products are recycled to maintain cellular homeostasis. This ability makes autophagy a good candidate for a survival mechanism in response to several stresses, including the tumor cell transformation. In particular, recent studies suggested that autophagy functions as a pro-death mechanism within different tumor contexts. It is, however, widely reported that autophagy… CONTINUE READING

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