Autophagy and ageing: implications for age-related neurodegenerative diseases.

  title={Autophagy and ageing: implications for age-related neurodegenerative diseases.},
  author={Bernadette Carroll and Graeme Hewitt and Viktor I. Korolchuk},
  journal={Essays in biochemistry},
Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An area of intense research interest is the role and indeed the fate of autophagy during cellular and… 

Figures from this paper

Autophagy: 'Self-Eating' Your Way to Longevity.

This chapter summarises current knowledge regarding the relationship between autophagy and ageing and outlines some strategies that can be implemented to promote the anti-ageing effects of Autophagy to improve human health and lifespan.

How autophagy can restore proteostasis defects in multiple diseases?

Various pharmacological findings linked with the induction and suppression of autophagy mechanism are summarized and their promising preclinical and clinical applications to provide therapeutic solutions against neurodegeneration are summarized.

Autophagy in neuronal cells: general principles and physiological and pathological functions

The role of autophagy in four types of neurodegenerative diseases, i.e., amyotrophic lateral sclerosis and frontotemporal dementia, prion diseases, lysosomal storage diseases, and Parkinson’s disease is focused on.

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration

The interplay among oxidative stress, proteinopathy, and neuroinflammation at the early stages of neurodegenerative diseases is discussed and the use of the Nrf2-ARE pathway as a potential therapeutic strategy based on these molecular mechanisms to develop transformative medicines is discussed.

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases

The role of ER stress response pathways in age-dependent neurodegeneration is reviewed to give a brief overview of the role they play in lifespan regulation under both normal and disease states.

Proteostasis, oxidative stress and aging

What We Learned From Big Data for Autophagy Research

In this review, recent applications of in silico investigations and big data analyses of the autophagy process in various biological systems are outlined.



Control of autophagy as a therapy for neurodegenerative disease

The ways in which dysfunctions at multiple stages in the autophagic pathways contribute to numerous neurological disorders are highlighted through the use of examples of Mendelian and complex conditions, including Alzheimer disease, Parkinson disease and forms of motor neuron disease.

Regulation of the aging process by autophagy.

Regulation of mammalian autophagy in physiology and pathophysiology.

This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

It is demonstrated that expression of several autophagy genes is reduced in Drosophila neural tissues as a normal part of aging, indicating that genetic or age-dependent suppression ofAutophagy is closely associated with the buildup of cellular damage in neurons and a reduced lifespan, while maintaining the expression of a rate-limiting Autophagy gene prevents the age- dependent accumulation of damage in neuron and promotes longevity.

Autophagy: A double-edged sword in Alzheimer’s disease

Autophagy is a major protein degradation pathway that is essential for stress-induced and constitutive protein turnover. Accumulated evidence has demonstrated that amyloid-β (Aβ) protein can be

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

It is shown that reactive oxygen species (ROS) serve as common mediators upstream of the activation of the type III PI3 kinase, which is critical for the initiation of autophagy, and it is demonstrated thatAutophagy is transcriptionally down-regulated during normal aging in the human brain.

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

It is shown that CMA activity is maintained until advanced ages if the decrease in the receptor abundance is prevented and that preservation of autophagic activity is associated with lower intracellular accumulation of damaged proteins, better ability to handle protein damage and improved organ function.

Induction of autophagy by spermidine promotes longevity

Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.

SIRT1: regulation of longevity via autophagy.

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Recent studies on redox signalling in the regulation of autophagy are highlighted, in the context of the basic mechanisms of mitophagy, and the impact ofautophagy on mitochondrial function and accumulation of reactive species is discussed.